Indications for use Valium
Neurosis, neurasthenia, hysteria, reactive depression, agoraphobia, insomnia associated with the breaking phase of sleep, Meniere’s disease, spastic paralysis, withdrawal symptoms in patients with alcoholism, status epilepticus, epilepsy, premedication before surgery and endoscopic manipulations; LSD poisoning.
Valium (Diazepam) dosage and administration
Adults with neurosis, neurasthenia, hysteria, spastic paralysis, prevention of epileptic seizures: 2-10 mg 3-4 times a day. Withdrawal symptoms in patients with alcoholism: 10 mg 3-4 times in the first day, followed by a daily dose reduction to 5 mg 3-4 times a day. In elderly patients with single dose of 1-2.5 mg 3-4 times a day. If necessary, the dose gradually increased. Children over 6 months of drug administered at a dose of 1-2.5 mg 3-4 times a day (if necessary, the dose gradually increased).
Increased sensitivity, acute liver disease and kidney violation of their duties, myasthenia gravis, angle-closure glaucoma, I trimester of pregnancy, breast-feeding.
Valium side effects
Addictive, paradoxical reactions (development of anxiety, hallucinations, seizures, insomnia), reaction speed and concentration, drowsiness, blurred short-term memory, ataxia, dysarthria, headache, dizziness, hypotension, bradycardia, prolonged use of liver and kidney damage, atony bowel, loss of libido and potency, reactions to the injection site, the syndrome of “lifting” syndrome-effect (decreased performance, muscle weakness), and allergic reactions.
Symptoms: drowsiness, impaired consciousness, coma, depression refleksov.Lechenie: gastric lavage, intravenous fluids, and flumazenil (antagonist of benzodiazepines), artificial ventilation.
Action of Valium
Valium has anxiolytic, anticonvulsant, muscle relaxant, sedative, hypnotic effect. Anxiolytic activity is apparent ability to arrest the internal anxiety, fear, anxiety, tension. Diazepam has a dose-dependent effect on the central nervous system: at low (2-15 mg per day) – stimulating, in large (15 mg per day or more) – sedative. Central myorelaxation effect is due to inhibition of spinal polysynaptic reflexes. Causes a decrease in blood pressure (weak sympatholytic), expansion of coronary vessels and increases the resistance of the brain to hypoxia. Increases the pain threshold. Possesses strong antiparoksizmalnym and anticonvulsant effects that manifest suppression sympathoadrenal and parasympathetic paroksizmov.Posle inside absorbed about 75% of the dose. The maximum concentration achieved in 1-1.5 hours. Biotransformation in the liver with the formation of active metabolites. Half-life in infants about 30 hours in adults and older – 48 and 100 hours respectively. Liver pathology half-life is prolonged to 4 days. Shown in the kidneys (approximately 90%) in the form of conjugates, at least 10% – in the feces, to about 2% – in the urine unchanged.
Valium enhances the effects of alcohol, anticonvulsants and antihypertensives, analgesics, hypnotics. MAO inhibitors, analeptic agents, stimulants reduce the activity.
Valium storage conditions
Valium should be stored in a dry, dark place at room temperature.